Related Experiment Video
Updated: Jun 28, 2025
07:16
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
13.6K
Forskolin reverses the O-GlcNAcylation dependent decrease in GABAAR current amplitude at hippocampal synapses
Shekinah Phillips1, John C Chatham1, Lori L McMahon2
1University of Alabama at Birmingham.
Research Square
|April 25, 2024
Summary
Increased O-GlcNAcylation enhances GABAergic transmission by unmasking neurosteroid potentiation of inhibitory postsynaptic currents in hippocampal cells.
Area of Science:
- Neuroscience
- Cellular Biology
- Biochemistry
Background:
- GABAergic transmission is modulated by post-translational modifications (PTMs) like phosphorylation.
- O-GlcNAcylation, a PTM involving O-linked β-N-acetylglucosamine, was previously shown to depress GABAergic currents.
- The interaction between O-GlcNAcylation and phosphorylation in regulating GABAergic signaling remains unclear.
Conclusions:
- Heightened O-GlcNAcylation facilitates the potentiation of synaptic inhibition by neurosteroids.
- This suggests that the neurosteroid binding site on synaptic GABAA receptors becomes accessible under conditions of increased O-GlcNAcylation.
- O-GlcNAcylation plays a critical role in regulating the plasticity of GABAergic signaling.
More Related Videos
Related Concept Videos
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
2.2K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.2K
01:18Antiepileptic Drugs: GABAergic Pathway Potentiators
388
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
388
01:12GPCR Desensitization
6.0K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
6.0K
01:21G-Protein Gated Ion Channels
4.6K
GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
Sensory...
4.6K