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Published on: February 9, 2019
Lipid-based nanoparticles as drug delivery carriers for cancer therapy
Ibtesam Waheed1, Anwar Ali2,3, Huma Tabassum4
1Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Abstract:
Cancer is a severe disease that results in death in all countries of the world. A nano-based drug delivery approach is the best alternative, directly targeting cancer tumor cells with improved drug cellular uptake. Different types of nanoparticle-based drug carriers are advanced for the treatment of cancer, and to increase the therapeutic effectiveness and safety of cancer therapy, many substances have been looked into as drug carriers. Lipid-based nanoparticles (LBNPs) have significantly attracted interest recently. These natural biomolecules that alternate to other polymers are frequently recycled in medicine due to their amphipathic properties. Lipid nanoparticles typically provide a variety of benefits, including biocompatibility and biodegradability. This review covers different classes of LBNPs, including their characterization and different synthesis technologies. This review discusses the most significant advancements in lipid nanoparticle technology and their use in medicine administration. Moreover, the review also emphasized the applications of lipid nanoparticles that are used in different cancer treatment types.
Insights
Lipid-based nanoparticles (LBNPs) offer a promising nano-based drug delivery strategy for cancer treatment. These biocompatible carriers enhance drug uptake and therapeutic effectiveness, improving cancer therapy safety.
Area of Science:
- Nanomedicine
- Biotechnology
- Oncology
Background:
- Cancer remains a global health challenge requiring innovative therapeutic strategies.
- Nanoparticle-based drug delivery systems show potential for targeted cancer treatment.
- Lipid-based nanoparticles (LBNPs) are emerging as advanced drug carriers due to their favorable properties.
Purpose of the Study:
- To review different classes of lipid-based nanoparticles (LBNPs).
- To discuss LBNP characterization and synthesis technologies.
- To highlight advancements and applications of LBNPs in cancer therapy.
Main Methods:
- Comprehensive literature review of lipid-based nanoparticles in cancer treatment.
- Analysis of LBNP properties, including biocompatibility and biodegradability.
- Examination of synthesis methods and characterization techniques for LBNPs.
Main Results:
- LBNPs demonstrate significant potential for targeted drug delivery to cancer cells.
- Various classes of LBNPs offer improved cellular uptake and therapeutic efficacy.
- Lipid nanoparticles provide benefits such as biocompatibility and biodegradability.
Conclusions:
- Lipid-based nanoparticles represent a key advancement in nanomedicine for cancer therapy.
- LBNPs enhance the safety and effectiveness of cancer treatments.
- Further research into LBNP applications promises improved patient outcomes.
