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Cancer Survival Analysis01:21

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  11. Prognosis Value Of Heat-shock Proteins In Esophageal And Esophagogastric Cancer: A Systematic Review And Meta-analysis.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prognosis Value Of Heat-shock Proteins In Esophageal And Esophagogastric Cancer: A Systematic Review And Meta-analysis.

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Development of Compendium for Esophageal Squamous Cell Carcinoma
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Prognosis value of heat-shock proteins in esophageal and esophagogastric cancer: A systematic review and meta-analysis.

Eric Toshiyuki Nakamura1,2, Amanda Park3, Marina Alessandra Pereira1

  • 1Department of Gastroenterology, Instituto do Câncer, Hospital das Clínicas da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246000, Brazil.

World Journal of Gastrointestinal Oncology
|April 25, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Heat shock proteins (HSPs) like HSP40 and HSP60 correlate with better survival in esophageal cancers. However, heat shock factor 1 (HSF1) indicates poorer outcomes and increased lymph node metastasis.

Keywords:
Esophageal neoplasmsHeat-shock proteinsHeat-shock responseMeta-analysis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Heat shock proteins (HSPs) are crucial for cellular protection against stress.
  • HSPs are frequently overexpressed in various cancers.
  • The prognostic role of HSPs and their regulators (HSF1, CHIP) in esophageal cancer remains unclear.

Purpose of the Study:

  • To examine the association between HSP expression and prognosis in esophageal and esophagogastric cancer.
  • To clarify the clinical significance of HSPs in these gastrointestinal malignancies.

Main Methods:

  • A systematic review adhering to PRISMA guidelines was performed.
  • Searched Embase, PubMed, Cochrane, and LILACS for relevant cohort, case-control, and cross-sectional studies.
  • Analyzed data from 3465 patients across 27 studies, focusing on overall survival and lymph node metastasis.
Prognosis

Main Results:

  • HSP40 and HSP60 expression were linked to improved 3-year overall survival (OS).
  • Heat shock factor 1 (HSF1) expression was associated with poorer 3-year OS and increased lymph node metastasis.
  • No significant associations were found for other HSP families regarding survival or metastasis.

Conclusions:

  • Specific HSP families (HSP40, HSP60) and HSF1 are significant prognostic markers in esophageal and esophagogastric cancers.
  • HSP40 and HSP60 may indicate better survival, while HSF1 suggests a worse prognosis and higher metastatic potential.