[Effect of L-Type Amino Acid Transporter 1 Expression on Clinicopathological Features and Prognosis of Non-Hodgkin's Lymphoma]
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View abstract on PubMed
Summary
This summary is machine-generated.High expression of L-type amino acid transporter 1 (LAT1) in non-Hodgkin's lymphoma (NHL) tissues is linked to advanced disease and poorer survival. LAT1 is a significant risk factor for mortality in NHL patients.
Area Of Science
- Oncology
- Molecular Biology
- Cancer Research
Context
- Non-Hodgkin's lymphoma (NHL) is a heterogeneous group of lymphoid malignancies.
- Understanding molecular markers associated with NHL progression and prognosis is crucial for patient management.
Purpose
- To investigate the expression of L-type amino acid transporter 1 (LAT1) in NHL tissues.
- To correlate LAT1 expression with clinicopathological features and patient prognosis.
Summary
- Immunohistochemistry detected LAT1 expression in 92 NHL patients.
- Increased LAT1 expression correlated with advanced Ann Arbor stage, extranodal infiltration, and higher Ki-67 levels.
- High LAT1 expression was associated with lower remission rates and significantly reduced 3-year survival.
Impact
- LAT1 expression is a significant prognostic indicator in NHL.
- LAT1 may serve as a potential therapeutic target in NHL treatment.
- Findings contribute to personalized medicine approaches for NHL patients.
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