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[Clinical use of ceftizoxime suppositories in pediatric infection]
Insights
Ceftizoxime suppositories (CZX-S) offer a safe and effective treatment for pediatric infections when oral or IV routes are unsuitable. This antibiotic preparation demonstrated positive clinical and microbiological outcomes in children with bronchitis and urinary tract infections.
Area of Science:
- Pediatric Infectious Diseases
- Pharmacology
Background:
- Ceftizoxime suppositories (CZX-S) were evaluated for pediatric use.
- Assessed efficacy in children with acute bronchitis and urinary tract infections.
Observation:
- Five children received CZX-S (125-250 mg potency) thrice daily.
- Clinical response was "markedly effective" in 2 and "effective" in 3 patients.
- Microbiological eradication of S. aureus and E. coli observed.
Findings:
- CZX-S demonstrated significant clinical effectiveness in treating pediatric infections.
- Microbiological success included eradication and reduction of bacterial strains.
- No adverse reactions or abnormal laboratory findings were reported.
Implications:
- CZX-S presents a viable alternative for pediatric antibiotic therapy.
- Useful for children unable to take oral or intravenous medications.
- Supports the clinical utility of suppository formulations in pediatric care.
Abstract:
Ceftizoxime suppositories (CZX-S) were given to 5 children comprising 3 with acute bronchitis, 1 with acute bronchitis complicated by enteritis, and 1 with acute urinary tract infection, in doses of 12.5 12.5-17.4 mg/kg with 1 suppository containing 125 mg or 250 mg (potency) given 3 times a day. The clinical response was "markedly effective" in 2 and "effective" in 3. Microbiologically CZX-S caused a eradication of 1 strain each of S. aureus and E. coli and caused a decrease of organisms in 1 strain of S. aureus. There were no adverse reactions or abnormal laboratory test findings attributable to CZX-S. In conclusion, CZX-S proved to be a clinically useful antibiotic preparation for the treatment of infection in children not suited to treatment with oral or intravenous preparations.