Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

2.4K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.4K
Abnormal Proliferation02:23

Abnormal Proliferation

4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

15.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral Mucositis in Oncopediatric Patients: MTX and MMP-1, MMP-8, MMP-13 Gene Polymorphisms.

Oral diseases·2026
Same author

Case Report of a Child With an Extranumerary Upper Limb: Treatment and Literature Review.

Hand (New York, N.Y.)·2025
Same author

Can Global DNA Methylation Be Influenced by Polymorphisms in Genes Involved in Epigenetic Mechanisms? A Review.

Genes·2025
Same author

Surgical interventions for treating hallux valgus and bunions.

The Cochrane database of systematic reviews·2024
Same author

Ankle osteoarthritis: comprehensive review and treatment algorithm proposal.

EFORT open reviews·2022
Same author

Ankle Osteoarthritis Aetiology.

Journal of clinical medicine·2021

Related Experiment Video

Updated: Jun 27, 2025

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
08:59

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions

Published on: April 18, 2015

10.4K

MMP-1, MMP-8, and MMP-13 Gene Polymorphisms and Haplotype Is a Risk Factor for Dupuytren Contracture: A Case-Control

Mauricio P Rodrigues1, Larissa H Tissi2, Vinicius M Oliveira2

  • 1Department of Orthopaedics, Foot and Ankle Service, University of São Paulo, Brazil.

Hand (New York, N.Y.)
|April 25, 2024
PubMed
Summary
This summary is machine-generated.

Genetic variations in matrix metalloproteinases (MMPs) are associated with Dupuytren contracture (DC). Specific single nucleotide polymorphisms (SNPs) in MMP-1, MMP-8, and MMP-13 genes, individually and in haplotype, represent a significant risk factor for DC.

Keywords:
Dupuytren contracturegenetic polymorphismhaplotypematrix metalloproteinasesrisk factor

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.4K
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.1K

Related Experiment Videos

Last Updated: Jun 27, 2025

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
08:59

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions

Published on: April 18, 2015

10.4K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.4K
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.1K

Area of Science:

  • Genetics
  • Molecular Biology
  • Medical Research

Background:

  • Increased expression of matrix metalloproteinases (MMPs) is observed in Dupuytren contracture (DC) tissue.
  • Genetic polymorphisms, specifically single nucleotide polymorphisms (SNPs), in MMP genes may influence their transcription levels.
  • Haplotype analysis, examining groups of alleles, can offer greater insight into the association between SNPs and DC.

Purpose of the Study:

  • To investigate the individual and combined influence of MMP-1 g.-1607 G>GG (rs1799750), MMP-8 g.-799 C>T (rs11225395), and MMP-13 g.-77 A>G (rs2252070) SNPs on Dupuytren contracture.
  • To evaluate the role of these specific SNPs and their haplotypes in the development of DC.

Main Methods:

  • A case-control study involving 60 DC patients and 100 controls matched for age and gender.
  • Genomic DNA extraction from saliva samples followed by genotyping using polymerase chain reaction-restriction fragment length polymorphism.
  • Statistical analyses included Mann-Whitney U test, Chi-squared test, and PHASE and R software for allele, genotype, and haplotype frequency comparisons.

Main Results:

  • Significant differences in allele and genotype frequencies were found for the studied SNPs between DC patients and controls.
  • The 2G allele in MMP-1 (rs1799750), T allele in MMP-8 (rs11225395), and A allele in MMP-13 (rs2252070) were identified as risk alleles for DC.
  • Global haplotype analysis revealed a significant association between specific haplotypes and the presence of Dupuytren contracture.

Conclusions:

  • The studied SNPs in MMP-1, MMP-8, and MMP-13 genes, both individually and as haplotypes, are confirmed risk factors for Dupuytren contracture.
  • These genetic variations may serve as potential diagnostic and prognostic markers for DC.
  • Further research into these genetic markers could lead to improved understanding and management of Dupuytren contracture.