An endothelial-related prognostic index for bladder cancer patients
Deng-Xiong Li1, Rui-Cheng Wu1, Jie Wang1
1Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Discover Oncology
|April 25, 2024
Summary
We developed an endothelial-associated prognostic index (EPI) using gene expression data to predict bladder cancer patient outcomes. The EPI identifies patients likely to respond to immunotherapy or chemotherapy, aiding precision medicine.
Area of Science:
- Oncology
- Genomics
- Bioinformatics
Background:
- Endothelial cells significantly influence bladder cancer (BC) prognosis within the tumor microenvironment.
- Understanding endothelial cell impact is crucial for improving BC patient outcomes.
Purpose of the Study:
- To elucidate the impact of endothelial cells on bladder cancer patient outcomes.
- To develop a prognostic index based on endothelial cell-associated genes.
Main Methods:
- Integrated single-cell and bulk RNA sequencing data from online databases.
- Utilized R version 3.6.3 for developing and validating an endothelial-associated prognostic index (EPI).
Main Results:
- Formulated an EPI comprising six genes (CYTL1, FAM43A, GSN, HSPG2, RBP7, SLC2A3) with significant prognostic value.
- EPI correlates with endothelial cell function and immune processes, predicting immunotherapy response (low-risk) and chemotherapy sensitivity (high-risk).
- Validated EPI in The Cancer Genome Atlas (TCGA) and an external dataset.
Conclusions:
- Identified key endothelial cell-related genes for bladder cancer prognosis.
- Developed a novel EPI for bladder cancer patients, supporting precision medicine strategies.
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