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External validation of the colorectal cancer risk score LiFeCRC using food frequency questions in the HUNT study

  • 0Department of Surgery, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway. siv.s.brenne@ntnu.no.
International Journal of Colorectal Disease +

|

April 25, 2024

|

April 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

A modified LiFeCRC score using simple food frequency data effectively predicts colorectal cancer (CRC) risk. This tool can aid in lifestyle changes and screening for CRC prevention.

Area Of Science

  • Oncology
  • Preventive Medicine
  • Epidemiology

Background

  • Colorectal cancer (CRC) incidence is rising globally.
  • Effective CRC risk assessment requires easily interpretable lifestyle data.
  • Existing risk models vary in clinical applicability.

Purpose Of The Study

  • To externally validate the LiFeCRC score in an independent Norwegian population.
  • To assess the utility of simplified food frequency questionnaires within the LiFeCRC score.
  • To evaluate the score's performance across different demographics and cancer subtypes.

Main Methods

  • A longitudinal health study (HUNT) in Norway included 78,580 participants.
  • Food frequency data on vegetable, dairy, processed meat, and sugar consumption were collected.
  • The LiFeCRC score was calculated, and cancer incidence was tracked over a median of 10 years.

Main Results

  • The LiFeCRC score demonstrated good discrimination for overall CRC (AUC 0.77).
  • Performance was robust in sex-specific models and included older adults and patients with diabetes.
  • The score showed better discrimination for colon cancer (AUC 0.80) than rectal cancer (AUC 0.72), with the highest accuracy for female colon cancer (AUC 0.81).

Conclusions

  • A modified LiFeCRC score, incorporating accessible clinical variables and food frequency data, can identify individuals at risk of CRC.
  • This score has the potential to enhance primary prevention strategies.
  • It may motivate individuals towards healthier lifestyle choices or participation in CRC screening programs.

Keywords:

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