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Updated: Jun 27, 2025

Fluorescence-Guided Matrix-assisted Laser Desorption/Ionization with Laser-Induced Postionization Mass Spectrometry of Individual Rat Neural Cells
Published on: May 23, 2025
Matrix-assisted laser desorption/ionization mass spectrometry imaging for quorum sensing
Christel Kuik1, Sanne W G van Hoogstraten2, Jacobus J C Arts2,3
1Maastricht MultiModal Molecular Imaging institute (M4i), Maastricht University, Maastricht, the Netherlands.
Abstract:
Quorum sensing (QS) is a complex communication system in bacteria, directing their response to the environment. QS is also one of the main regulators of bacterial biofilms' formation, maturation and dispersion. Matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) is a molecular imaging technique that allows the mapping of QS molecules in bacterial biofilms. Here, we highlight the latest advances in MALDI-MSI in recent years and how this technology can improve QS understanding at the molecular level.
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