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Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

Lyle G Best1,2, Esther Erdei3, Karin Haack4

  • 1Epidemiology Division, Missouri Breaks Industries Research, Inc. Eagle Butte, SD, United States of America.

Plos One
|April 25, 2024
PubMed

Insights

A specific CRP gene variant, rs1205, is linked to increased COVID-19 hospitalization or death risk in American Indian communities. This genetic factor may influence COVID-19 severity, highlighting host genetics in disease outcomes.

Area of Science:

  • Genetics
  • Immunology
  • Infectious Disease Epidemiology

Background:

  • Host genetic variations influence COVID-19 incidence and severity.
  • The C-reactive protein (CRP) gene plays a role in the innate immune system.
  • CRP gene variants have been previously associated with infectious diseases and vaccine responses.

Purpose of the Study:

  • To investigate the association between specific genetic variants, including rs1205 in the CRP gene, and COVID-19 outcomes.
  • To determine if host genetic factors contribute to the risk of severe COVID-19.

Main Methods:

  • Analysis of genetic data and COVID-19 outcomes (death or hospitalization) from 3,780 participants in the Strong Heart and Strong Heart Family studies.
  • Examined 21 candidate variants, focusing on rs1205 in the CRP gene.
  • Statistical analysis adjusted for age, sex, center, body mass index, cardiovascular disease history, and genetic relatedness.

Main Results:

  • The rs1205 variant in the CRP gene showed a nominally significant association with COVID-19 death or hospitalization (OR 1.859, p=0.049) in a T-dominant model.
  • This association remained significant after adjusting for clinical factors and participant relatedness.
  • The association was stronger in a younger subset of participants.

Conclusions:

  • A T-dominant genotype of the rs1205 variant in the CRP gene is associated with increased risk of COVID-19 hospitalization or death.
  • Host genetic factors, specifically CRP gene variants, may play a role in COVID-19 severity.
  • Further research in diverse populations and on other CRP gene variants is recommended.
Abstract

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