Related Experiment Video
Updated: Jun 27, 2025
08:11
Quantitative Analysis of Chromatin Proteomes in Disease
Published on: December 28, 2012
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Proteomics, Human Environmental Exposure, and Cardiometabolic Risk
Andrew S Perry1, Kai Zhang2, Venkatesh L Murthy3
1Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN (A.S.P., S.Z., J.J.C., R.V.S.).
Circulation Research
|April 25, 2024
Summary
Environmental exposures are linked to circulating proteins that indicate cardiovascular and respiratory disease risk. This inflammatory-metabolic proteome highlights individuals susceptible to cardiometabolic diseases and adverse health outcomes.
Area of Science:
- Environmental health
- Proteomics
- Cardiovascular epidemiology
Background:
- Mechanisms linking environmental exposures to cardiovascular disease are not fully understood.
- Identifying circulating proteomic signatures can elucidate these links.
- Observational cohort studies are crucial for examining these associations.
Purpose of the Study:
- To identify circulating proteomic signatures associated with environmental exposures.
- To investigate the relationship between these proteomic signatures and cardiometabolic/respiratory diseases.
- To explore the predictive value of proteomic signatures for cardiovascular disease and mortality.
Main Methods:
- Utilized penalized and ordinary linear regression in the CARDIA study (≈3000 participants) to test associations between >6500 proteins and 29 environmental exposures.
- Employed Cox models in the Framingham Heart Study (FHS) and Jackson Heart Study (JHS) (>3500 participants) to assess prospective relations of envirome proteomic signatures with cardiovascular disease and mortality.
- Included environmental factors such as built environment, green space, air pollution, temperature, and social vulnerability indicators.
Main Results:
- Proteomic signatures revealed novel/established cardiovascular disease-relevant pathways including DNA damage, fibrosis, inflammation, and mitochondrial function.
- Envirome proteomic signatures were broadly associated with cardiometabolic disease and respiratory phenotypes (e.g., BMI, lipids, left ventricular mass) in CARDIA, with replication in FHS/JHS.
- A proteomic signature of social vulnerability was significantly associated with increased risk of cardiovascular disease and mortality, independent of clinical risk factors.
Conclusions:
- Environmental exposures are associated with an inflammatory-metabolic proteome.
- This proteome can identify individuals at higher risk for cardiometabolic disease and respiratory phenotypes/outcomes.
- Further research is needed to understand the dynamic impact of environmental factors on cardiometabolic health.
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