Uveal melanoma incidence and survival analysis in Portugal between 2013 and 2022
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View abstract on PubMed
Summary
This summary is machine-generated.Early diagnosis of uveal melanoma (UM) improves outcomes. This study of Portuguese UM patients shows lower AJCC stages and smaller tumor thickness correlate with better survival and reduced metastasis.
Area Of Science
- Ophthalmology
- Oncology
- Epidemiology
Background
- Uveal melanoma (UM) is the most common primary intraocular malignancy.
- Understanding its epidemiology and clinical characteristics is crucial for effective management.
Purpose Of The Study
- To comprehensively analyze the clinical features and epidemiology of uveal melanoma in Portugal.
- To evaluate treatment outcomes and survival rates at the National Reference Centre (NRC).
Main Methods
- Prospective observational study of 316 UM patients diagnosed at the Portuguese NRC (July 2013 - December 2022).
- Data collected included demographics, tumor characteristics, AJCC staging, treatments, and survival outcomes.
- Analysis of local disease control, patient survival, and distant metastases.
Main Results
- The mean annual incidence of UM in Portugal (2014-2022) was 2.4 cases per million.
- Five-year survival and distant metastases-free survival (DMFS) rates were 84.9% and 79.4%, respectively.
- Higher AJCC stages, enucleation, and increased tumor thickness were linked to poorer survival and DMFS.
Conclusions
- This study provides extensive data on Portuguese UM epidemiology.
- Early diagnosis and treatment, characterized by lower AJCC stages and reduced tumor thickness, are critical for improved survival and DMFS.
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