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Research Progress on Cognitive Frailty in Older Adults with Chronic Kidney Disease

Yuqing Yuan1, Jing Chang1, Qianmei Sun1

  • 1Department of Internal Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Kidney & Blood Pressure Research
|April 25, 2024
PubMed

Insights

Older adults with chronic kidney disease (CKD) have higher rates of cognitive frailty. This review covers its concept, screening, and management in CKD patients.

Area of Science:

  • Gerontology
  • Nephrology
  • Neuroscience

Background:

  • The aging population presents increasing medical challenges, with a growing proportion of elderly individuals diagnosed with chronic kidney disease (CKD).
  • Older patients are a high-risk demographic for frailty and cognitive impairment.

Purpose of the Study:

  • To provide a comprehensive review of cognitive frailty in patients with chronic kidney disease (CKD).
  • To explore the concept, epidemiology, screening, prevention, and treatment of cognitive frailty in this population.

Main Methods:

  • Literature review focusing on cognitive frailty in older adults with CKD.
  • Synthesis of existing research on the concept, epidemiology, screening, prevention, treatment, and pathogenesis.

Main Results:

  • Cognitive frailty, defined as cognitive dysfunction due to physiological factors (excluding dementia), is characterized by the coexistence of physical frailty and cognitive impairment.
  • The prevalence of frailty is significantly higher in CKD patients compared to the general population.
  • Research on cognitive frailty, especially in older CKD patients, is limited.

Conclusions:

  • Cognitive frailty is a significant concern in older adults with CKD.
  • Further research and targeted interventions are needed to address cognitive frailty in this vulnerable group.
  • This review aims to consolidate current knowledge and guide future clinical practice and research.
Abstract

Keywords:
AgeingChronic kidney diseaseCognitive frailtyFrailtyHaemodialysis

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