Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Necrosis01:16

Necrosis

4.5K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.5K
Types of Toxins01:36

Types of Toxins

1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

178.2K
Overview
178.2K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

1.4K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.

Molecular medicine reports·2018
Same author

Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury.

JACC. Basic to translational science·2018
Same author

Oxidized fish oil injury stress in Megalobrama amblycephala: Evaluated by growth, intestinal physiology, and transcriptome-based PI3K-Akt/NF-κB/TCR inflammatory signaling.

Fish & shellfish immunology·2018
Same author

High Mobility Group B-1 (HMGB-1) Promotes Apoptosis of Macrophage-Derived Foam Cells by Inducing Endoplasmic Reticulum Stress.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology·2018
Same author

Single-Ring Magnetic Levitation Configuration for Object Manipulation and Density-Based Measurement.

Analytical chemistry·2018
Same author

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology·2018

Related Experiment Video

Updated: Jun 27, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

956

Ferroptosis implication in environmental-induced neurotoxicity.

Yiping Zhang1, Jun Xie1

  • 1School of Life Sciences, Fudan University, Shanghai 200438, China; Wanchuanhui (Shanghai) Medical Technology Co., Ltd, Shanghai 201501, China.

The Science of the Total Environment
|April 25, 2024
PubMed
Summary

Environmental factors can cause neurotoxicity through ferroptosis, a cell death pathway involving iron. This review examines how various agents trigger ferroptosis, offering insights into protective strategies against neurological damage.

Keywords:
AnestheticsEnvironmentFerroptosisMetalNanoparticleNeurotoxicityPollutionProgrammed cell deathSevoflurane

More Related Videos

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

189
Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

8.1K

Related Experiment Videos

Last Updated: Jun 27, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

956
Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

189
Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

8.1K

Area of Science:

  • Neuroscience
  • Toxicology
  • Cell Biology

Background:

  • Neurotoxicity threatens the nervous system via diverse agents.
  • Apoptosis was the primary recognized cell death pathway in neurotoxicity.
  • Emerging evidence implicates ferroptosis in neurotoxic events.

Purpose of the Study:

  • Review ferroptosis in environmental neurotoxicity.
  • Elucidate mechanisms of ferroptosis induction by environmental agents.
  • Explore preventive and therapeutic strategies against ferroptosis-mediated neurotoxicity.

Main Methods:

  • Comprehensive literature review.
  • Analysis of environmental agents inducing ferroptosis.
  • Examination of neurotoxicological mechanisms.

Main Results:

  • Ferroptosis is induced by various environmental agents including toxins, pollutants, and medical treatments.
  • Environmental factors trigger ferroptosis through distinct iron-dependent lipid peroxidation pathways.
  • Understanding these mechanisms is crucial for neuroprotection.

Conclusions:

  • Ferroptosis is a significant pathway in environmental neurotoxicity.
  • Targeting ferroptosis offers potential therapeutic avenues.
  • This review advances understanding for public health protection against neurotoxicants.