Related Experiment Video
Updated: May 5, 2026
09:01
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
10.0K
[Exploring the causality between intestinal flora and hyperplastic scars of human based on two-sample Mendelian
W T Chen1, X X Wang2, W L Zheng3
1The First Clinical College of Medicine, Guangdong Medical University, Zhanjiang 524023, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
|April 25, 2024
Summary
This study found that specific gut bacteria, including Intestinimonas and Ruminococcus2, may help prevent hypertrophic scars (HS). These findings suggest a causal link between gut microbiome and HS development.
Area of Science:
- Genetics
- Microbiology
- Dermatology
Context:
- Hypertrophic scars (HS) are a significant clinical concern.
- The role of the gut microbiome in scar formation is not well understood.
- Previous research has explored genetic predispositions to HS.
Purpose:
- To investigate the causal relationship between intestinal flora and hypertrophic scars (HS) in humans using a two-sample Mendelian randomization (TSMR) analysis.
- To identify specific gut bacteria that may influence HS development or prevention.
- To assess potential reverse causality between gut bacteria and HS.
Summary:
- Utilized genome-wide association study data for intestinal flora (n=18,473) and HS (n=208,248).
- Employed TSMR analysis with multiple methods (IVW, MR-Egger, weighted median, weighted mode) to analyze genetic variants (SNPs) associated with gut bacteria and HS.
- Identified a causal link where the genera Intestinimonas and Ruminococcus2 appear to have a protective effect against HS, with specific SNPs acting as protective factors.
Impact:
- Provides evidence for a causal role of specific gut bacteria in hypertrophic scar formation.
- Suggests potential therapeutic targets within the gut microbiome for HS prevention or treatment.
- Highlights the importance of the gut-skin axis in dermatological conditions.
Related Concept Videos
01:23Anatomy of the Intestines
65.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
65.3K
01:22Introduction to the Human Microbiota
222
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
222
01:30Development of Human Microbiota
68
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
68