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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Impact of Biologic Therapy on Key Cardiovascular Risk Parameters in a Psoriatic Cohort-a Retrospective Review

Joseph Joseph1,2, Kelvin Truong1,2, Serigne N Lo1,3

  • 1Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Dermatology and Therapy
|April 25, 2024
PubMed

Insights

Biologic therapy significantly improved psoriasis skin severity but did not alter cardiovascular disease risk factors like blood pressure or BMI after one year in patients with psoriasis.

Area of Science:

  • Dermatology and Cardiovascular Medicine
  • Immunodermatology
  • Clinical Research

Background:

  • Psoriasis is a known risk factor for cardiovascular disease (CVD).
  • Biologic agents represent a breakthrough in managing psoriatic skin lesions.
  • This study investigates the impact of continuous biologic treatment on CVD risk factors in psoriasis patients.

Purpose of the Study:

  • To evaluate changes in cardiovascular risk factors after one year of continuous biologic therapy in patients with chronic plaque psoriasis.
  • To assess the relationship between skin improvement and cardiovascular risk markers.

Main Methods:

  • Retrospective review of 106 patients with chronic plaque psoriasis treated with biologics.
  • Psoriasis Area and Severity Index (PASI) used to measure skin improvement.
  • Cardiovascular risk factors assessed included body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR).
  • Paired t-tests compared baseline and 1-year follow-up measurements.

Main Results:

  • Significant improvement in psoriasis severity (PASI reduction from 17.4 to 1.4, p < 0.001).
  • No statistically significant changes were observed in SBP, DBP, BMI, or HR after 1 year of treatment.
  • Mean BMI at baseline was 30 kg/m², with no significant change observed.

Conclusions:

  • One year of continuous biologic therapy leads to substantial skin improvement in psoriasis patients.
  • Despite significant dermatological benefits, biologic therapy did not demonstrate improvement in key cardiovascular disease risk factors within the study period.
  • Further research is needed to explore long-term cardiovascular outcomes and potential interventions in this patient population.
Abstract

Keywords:
Biologic therapyCardiovascular diseaseCardiovascular risk factorsPsoriasisRetrospective review

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