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Efficacy and safety of solifenacin combined with biofeedback in children with overactive bladder
1The Department of Pediatrics, West China Second University Hospital of Sichuan University, No 20 Third Section, Renmin Nan Road, Chengdu, Sichuan, 610041, China.
Insights
Combining solifenacin with biofeedback significantly improves overactive bladder (OAB) symptoms in children. This combination therapy offers a safe and effective treatment, showing rapid improvement, particularly for urge incontinence (UI).
Area of Science:
- Pediatric Urology
- Pharmacology
- Behavioral Therapy
Background:
- Overactive bladder (OAB) is a prevalent pediatric condition impacting daily life and self-esteem.
- Current treatments aim to improve quality of life for affected children.
Purpose of the Study:
- To assess the efficacy and safety of solifenacin combined with biofeedback in treating pediatric overactive bladder.
- To compare the combined therapy against solifenacin alone and biofeedback alone.
Main Methods:
- A study involving 45 children with OAB, divided into three groups: solifenacin, biofeedback, and combined therapy.
- Patients were categorized into non-urge incontinence (non-UI) and urge incontinence (UI) subgroups.
- Remission rates and side effects were monitored over 12 weeks.
Main Results:
- The combined therapy group showed significantly higher complete response rates (86.7% at 12 weeks) compared to solifenacin (67.8%) or biofeedback (60.0%) alone.
- Improvements in urodynamic parameters and functional bladder capacity were more pronounced in the combined group.
- Urge incontinence (UI) symptoms responded better than non-UI symptoms in the combined therapy group.
Conclusions:
- Solifenacin combined with biofeedback demonstrates high efficacy and good compliance for pediatric overactive bladder.
- The combination therapy achieved over 50% complete response rate within 2 weeks, especially for UI.
- This approach offers a promising treatment option for children with OAB, improving their quality of life.
Background:
Overactive bladder is a common chronic urological disorder in children, liable to impact normal social activities, disrupt sleep and even impair self-esteem. We aimed to evaluate the efficacy and safety of solifenacin combined with biofeedback for paediatric overactive bladder.
Method:
Forty-five children with overactive bladder were enrolled and divided into three groups: 15 patients in Group A were treated with solifenacin, 15 cases in Group B with biofeedback, and the other 15 patients in Group C with the combination of solifenacin plus biofeedback. Each group was subdivided into the non-urge incontinence (non-UI) and urge incontinence (UI) groups. The remission rates were compared among the three groups at 2, 4, 8 and 12 weeks from the beginning of treatment. The side effects of solifenacin were recorded and followed up.
Result:
After 2 weeks since initial treatment, the complete response rates were 33.3% (5/15), 20.0% (3/15), and 53.3% (8/15) in the three groups. At 4 weeks, the complete remission rates were 46.7% (7/15), 33.3% (5/15), and 60.0% (9/15) respectively. Moreover, the complete remission rates of the UI groups were higher than the non-UI groups (p < 0.05). At 8 weeks, the complete response rates were 53.3% (8/15), 40.0% (6/15), and 67.7% (10/15). At 12 weeks, the complete response rates were 67.8% (10/15), 60.0% (9/15), and 86.7% (13/15). The complete response rates were higher and urodynamic parameters were improved obviously in group C than the other two groups (p < 0.05) during the follow-ups. The median voiding frequency decreased and median functional bladder capacity increased obviously in Group C after 4 weeks (p < 0.05). Dry mouth was observed in 2 patients (4.4%). 2 patients experienced constipation (4.4%), and neither case was severe. The symptoms of these four patients had relieved by reducing the dose of solifenacin.
Conclusion:
Solifenacin combined with biofeedback had good efficacy and compliance for children experiencing overactive bladder. It took only 2 weeks to achieve the complete response rate over 50%, especially for the improvement of UI symptoms.
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