Related Experiment Video
Updated: Jun 27, 2025

CD Spectroscopy to Study DNA-Protein Interactions
Published on: February 10, 2022
House of CarDs: Functional insights into the transcriptional regulator CdnL
1Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abstract:
Regulation of bacterial transcription is a complex and multi-faceted phenomenon that is critical for growth and adaptation. Proteins in the CarD_CdnL_TRCF family are widespread, often essential, regulators of transcription of genes required for growth and metabolic homeostasis. Research in the last decade has described the mechanistic and structural bases of CarD-CdnL-mediated regulation of transcription initiation. More recently, studies in a range of bacteria have begun to elucidate the physiological roles of CarD-CdnL proteins as well as mechanisms by which these proteins, themselves, are regulated. A theme has emerged wherein regulation of CarD-CdnL proteins is central to bacterial adaptation to stress and/or changing environmental conditions.
Related Concept Videos
Cis-regulatory Sequences
Cooperative Binding of Transcription Regulators
Co-activators and Co-repressors
Master Transcription Regulators
RNA Polymerase II Accessory Proteins
Combinatorial Gene Control
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...

