A Horizontal and Longitudinal Study on the Changes of Aging Thyroid Function in Elderly Male Population
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Thyroid function in elderly men changes with age, with higher TSH and lower FT3 in the oldest group. Longitudinal and cross-sectional analyses reveal differing thyroid function trends over time, emphasizing individual variability in aging.
Area Of Science
- Endocrinology
- Geriatrics
- Thyroid Research
Background
- Limited longitudinal studies exist on thyroid function changes in the same individuals over extended periods.
- Understanding age-related thyroid function shifts in elderly men is crucial for clinical management.
Purpose Of The Study
- To retrospectively analyze thyroid function changes in elderly men over an 8-year period.
- To explore the impact of aging on thyroid function parameters in men with normal baseline thyroid function.
Main Methods
- Retrospective analysis of 354 elderly men's physical examination records from 2013-2020.
- Subjects were categorized into four age groups (<60, 60-69, 70-79, ≥80 years).
- Comparison of thyroid-stimulating hormone (TSH), reverse triiodothyronine (rT3), free triiodothyronine (FT3), and free thyroxine (FT4) levels cross-sectionally and longitudinally.
Main Results
- Initial analysis showed age negatively correlated with FT3 and positively with rT3 and TSH.
- Longitudinal analysis revealed significantly higher TSH in the ≥80 years group compared to younger groups.
- FT3 levels showed a trend of decreasing then increasing, while FT4 changes with age were unclear; rT3 increased with age in older groups.
Conclusions
- Thyroid function indices in elderly men exhibit age-dependent alterations, with distinct cross-sectional and longitudinal patterns.
- The oldest group (≥80 years) presented the highest TSH and lowest FT3 values.
- Individual variability in thyroid function changes with age necessitates careful consideration in clinical practice and research.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...