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Cost effectiveness of hepatitis C direct acting agents
Akshay Shetty1,2, Michelle Lee2, Julia Valenzuela2
1Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Expert Review of Pharmacoeconomics & Outcomes Research
|April 26, 2024
Summary
Direct-acting antivirals (DAAs) offer effective treatment for chronic hepatitis C (HCV). This review assesses the cost-effectiveness of DAAs, crucial for achieving the WHO
Area of Science:
- Hepatology
- Public Health
- Health Economics
Background:
- Direct-acting antivirals (DAAs) have revolutionized chronic hepatitis C (HCV) treatment.
- The World Health Organization aims for HCV elimination by 2030.
- Pan-genotypic HCV regimens simplify treatment and maintain high efficacy.
Purpose of the Study:
- To evaluate the cost-effectiveness of DAA treatment for chronic HCV.
- To analyze DAA cost-effectiveness across general, cirrhosis, and vulnerable patient populations.
Main Methods:
- This study is a review assessing existing literature.
- Focus is on economic evaluations of DAA therapies for HCV.
- Analysis considers diverse patient demographics and treatment scenarios.
Main Results:
- DAA treatment demonstrates significant clinical efficacy.
- Cost-effectiveness varies by population and healthcare system.
- Barriers like cost and access impact treatment scalability.
Conclusions:
- DAA therapy is a cornerstone for HCV elimination strategies.
- Targeted policies are essential to overcome access and cost barriers.
- Addressing vulnerable populations is critical for widespread HCV eradication.
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