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Caudate functional networks influence brain structural changes with aging.

Silvia Basaia1, Matteo Zavarella1,2, Giulia Rugarli1,2

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|April 26, 2024
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Summary
This summary is machine-generated.

Aging causes brain network changes, particularly in medial caudate regions. These areas show greater atrophy and altered connectivity, suggesting vulnerability in neurodegenerative disorders.

Keywords:
agingcaudateconnectomicsstructural MRIsubventricular zone

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Area of Science:

  • Neuroscience
  • Aging Research
  • Brain Imaging

Background:

  • Neurogenesis decline with aging is linked to brain atrophy.
  • Subventricular zone (SVZ) neuron precursor cells may influence striatal activity.
  • Aging-related neurogenesis decay could alter brain regions connected to the caudate nucleus.

Purpose of the Study:

  • To investigate the relationship between functional organization of caudate networks and structural brain changes in aging.
  • To compare functional connectivity and atrophy patterns of medial and lateral caudate networks across age groups.

Main Methods:

  • Recruited 152 subjects across three age groups: young (≤35), middle-aged (36-60), and elderly (≥60).
  • Utilized stepwise functional connectivity analysis to map caudate network connections in young adults.
  • Assessed brain atrophy using T1-weighted MRI images in all age groups.

Main Results:

  • Middle-aged and elderly adults showed decreased functional connectivity from the caudate, especially in frontal, parietal, temporal, and occipital regions.
  • Elderly individuals exhibited increased connectivity in these lobes compared to younger groups, but decreased connectivity in specific parietal and subcortical areas.
  • Medial caudate connected regions demonstrated greater atrophy in elderly subjects compared to lateral caudate connected regions.

Conclusions:

  • Brain regions connected to the medial caudate are more susceptible to age-related atrophy and network alterations than those linked to the lateral caudate.
  • Proximity to the subventricular zone may contribute to the observed vulnerability of medial caudate networks.
  • Stepwise functional connectivity analysis is a valuable tool for understanding SVZ-related network disruptions in neurodegenerative aging.