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Photothrombosis-induced Focal Ischemia as a Model of Spinal Cord Injury in Mice

Photothrombosis-induced Focal Ischemia as a Model of Spinal Cord Injury in Mice

Published on: July 16, 2015

Spinal cord watershed infarction after surgery.

Gia Nguyen¹, Giang-Kim Nguyen², Fanny Emilia Morón²

¹Touro College of Osteopathic Medicine, 60 Prospect Ave, Middletown, NY 10940, USA.

Radiology Case Reports

|April 26, 2024

Summary

Spinal cord watershed infarction is rare, often seen in elderly patients with atherosclerosis and hypoperfusion. This case highlights it as a complication of postoperative blood loss, showing characteristic imaging changes.

Keywords:

Hypotension Spinal cord infarction Subacute spinal cord infarct Watershed areas

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Area of Science:

Neurology
Vascular Neurology
Neuroradiology

Background:

Spinal cord infarction (SCI) is uncommon due to extensive collateral circulation.
Watershed SCIs typically affect elderly patients with atherosclerosis and global hypoperfusion.
Risk factors include surgery, dissection, coagulopathies, or idiopathic causes.

Observation:

A rare case of spinal cord infarction affecting both longitudinal and transverse watershed areas is presented.
This infarction occurred as a complication of significant postoperative blood loss.
The study details the imaging progression of the spinal cord infarct into the subacute phase.

Findings:

The spinal cord infarct demonstrated characteristic peripheral enhancement in the subacute phase.
This enhancement is attributed to the breakdown of the blood-spinal cord barrier.
Imaging findings illustrate the evolution of ischemic injury in the spinal cord.

Implications:

This case expands the understanding of rare spinal cord infarction etiologies.
It underscores the importance of considering SCI in patients with unexplained neurological deficits post-surgery.
The imaging findings provide insights into the pathophysiology and diagnostic markers of subacute SCI.