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Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
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Related Experiment Video

Updated: Jun 27, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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The structural connectome in ADHD.

Xuan Bu1,2,3, Miao Cao4,5, Xiaoqi Huang6

  • 1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.

Psychoradiology
|April 26, 2024
PubMed
Summary
This summary is machine-generated.

Attention-deficit/hyperactivity disorder (ADHD) is linked to brain dysconnectivity. Diffusion MRI studies reveal white matter alterations in ADHD patients, impacting symptoms and cognition, but more research is needed for clinical use.

Keywords:
attention-deficit/hyperactivity disorderconnectomicsdiffusion MRIwhite matter

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Area of Science:

  • Neuroscience
  • Radiology
  • Psychiatry

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is increasingly viewed as a disorder of brain dysconnectivity.
  • Diffusion magnetic resonance imaging (dMRI) studies have identified white matter structural connectome alterations in individuals with ADHD over the past decade.

Purpose of the Study:

  • To review recent dMRI-based structural connectome studies in ADHD.
  • To synthesize findings from voxel-, tractography-, and network-based analyses.
  • To explore the potential of structural connectome alterations as biomarkers for ADHD.

Main Methods:

  • Review of voxel-based dMRI studies.
  • Review of tractography-based dMRI studies.
  • Review of network-based dMRI studies.

Main Results:

  • Disrupted white matter microstructure in frontostriatal tracts, corpus callosum, corticospinal tracts, and cingulum bundle in ADHD.
  • Abnormal global and local network efficiency and nodal properties in prefrontal and parietal regions in ADHD structural connectomes.
  • Altered structural connectomes show potential for predicting ADHD symptoms and aiding diagnostic classification.

Conclusions:

  • Structural connectome abnormalities are potential neural underpinnings of ADHD psychopathology.
  • These findings suggest potential for imaging biomarkers in clinical ADHD evaluation.
  • Further research with larger, homogeneous samples and advanced dMRI techniques is necessary to validate findings and inform clinical practice.