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Updated: May 7, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Synthesis of 2-Aryl Indazole: Synthesis, Biological Evaluationand In-Silico Studies
Vamshi Krishna Atikala1,2, Siddique Akber Ansari3, Irfan Aamer Ansari4
1Department of Chemistry, Acharya Nagarjuna University, Guntur, 522510, Andhra Pradesh, India.
Abstract:
In this work, a highly effective synthesis technique for obtaining aryl indazole under mild circumstances is provided, using trimethyl phosphine as a powerful reagent. The procedure shows that a wide range of substrates can be investigated, yielding various 2-aryl indazole derivatives with acceptable to exceptional yields and a wide range of functional group tolerance. Additionally, based on In Silico studies tests were conducted to determine the anticancer activity In Vitro for all produced compounds (3 a-3 j) against A549, HT-29 and HepG2 cell lines. Compounds 3 c and 3 d, with IC50 values of 15, 53.55, 7.34, 7.10, 56.28, and 17.87 (μM) against A549, HT-29 and HepG2 respectively, showed significant anticancer activity.
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