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Related Experiment Videos

Ulcer formation and cytoprotection by acetazolamide.

A Robert, C Lancaster, J P Davis

    European Journal of Pharmacology
    |December 3, 1985
    PubMed
    Summary

    Acetazolamide, a carbonic anhydrase inhibitor, impacts gastric ulcers differently depending on the cause. It protects the stomach and small intestine from damage, but its mechanism remains unclear.

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    Area of Science:

    • Pharmacology
    • Gastroenterology

    Background:

    • Acetazolamide is a carbonic anhydrase inhibitor.
    • Its effects on gastric ulcer formation and gastrointestinal cytoprotection are not fully understood.

    Purpose of the Study:

    • To investigate the effects of acetazolamide on gastric ulcerogenicity and cytoprotection in rats.
    • To explore the potential role of prostaglandins in acetazolamide's cytoprotective effects.

    Main Methods:

    • Acetazolamide was administered orally and subcutaneously to rats.
    • Gastric ulcers were induced using indomethacin, acidified aspirin, and ethanol.
    • Cytoprotective effects were assessed by measuring lesion counts.
    • Prostaglandin E2 (PGE2) and 16,16-dimethyl PGE2 were used to evaluate interactions.

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    Main Results:

    • Acetazolamide increased indomethacin-induced ulcers but inhibited aspirin-induced ulcers.
    • It demonstrated dose-dependent cytoprotection against ethanol-induced gastric lesions and indomethacin-induced intestinal lesions.
    • Acetazolamide's cytoprotective effect was time-dependent and inhibited by indomethacin pretreatment, suggesting prostaglandin involvement.
    • It did not interfere with the antiulcer effects of exogenous PGE2.

    Conclusions:

    • Acetazolamide exhibits complex effects on ulcer formation, acting as both an ulcerogen and a protective agent depending on the inducing agent.
    • It possesses significant cytoprotective properties for both the stomach and small intestine.
    • The cytoprotective mechanism may involve the endogenous release of prostaglandins, although this requires further investigation.