Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives.

Area of Science:

• Neuroscience
• Cellular Biology
• Pharmacology

Background:

• Ischemic stroke causes significant neuronal damage through complex cellular and molecular events.
• RhoA/ROCK and mTOR signaling pathways are critically involved in the pathophysiology of ischemic brain injury.

Purpose of the Study:

• To review therapeutic strategies targeting RhoA/ROCK and mTOR signaling pathways in ischemic stroke.
• To explore the neuroprotective potential of targeting these pathways and discuss future research directions.

Main Methods:

• Literature review focusing on preclinical studies of RhoA/ROCK and mTOR signaling in stroke models.
• Analysis of the roles of these pathways in cytoskeletal dynamics, inflammation, cell growth, proliferation, and autophagy.

Main Results:

• Targeting RhoA/ROCK and mTOR pathways demonstrates neuroprotective effects in preclinical stroke models.
• Challenges include potential off-target effects and the need for tissue-specific targeting.

Conclusions:

• RhoA/ROCK and mTOR pathways represent promising therapeutic targets for ischemic stroke.
• Further research is needed to elucidate mechanisms, optimize treatments, and translate findings to clinical practice. MSC secretome also shows therapeutic potential.