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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Detection of NT-proBNP Using Optical Fiber Back-Reflection Plasmonic Biosensors.

Ana Sofia Assunção1, Miguel Vidal1, Maria João Martins1

  • 1i3N, Department of Physics, University of Aveiro, 3810-193 Aveiro, Portugal.

Biosensors
|April 26, 2024
PubMed
Summary
This summary is machine-generated.

New optical fiber biosensors can detect N Terminal pro-B-type Natriuretic Peptide (NT-proBNP), a key marker for heart failure. These point-of-care testing devices offer sensitive and rapid detection in biological fluids.

Keywords:
N-terminal B-type natriuretic peptide (NT-proBNP)gold plasmonicsoptical fiber uncladded tip biosensorssurface plasmon resonance (SPR)

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Diagnostics
  • Biosensor Technology

Background:

  • Heart failure (HF) is a major global health issue, leading to frequent hospitalizations and significant healthcare costs.
  • Elevated levels of N Terminal pro-B-type Natriuretic Peptide (NT-proBNP) are indicative of HF, creating a need for accessible diagnostic tools.
  • Point-of-care testing (POCT) devices are highly desired for real-time monitoring of NT-proBNP.

Purpose of the Study:

  • To develop and characterize optical fiber (OF) immunosensors for NT-proBNP detection.
  • To evaluate the sensitivity and limit of detection (LOD) of OF biosensors with varying core diameters.
  • To assess the potential of these biosensors for use in biological fluids.

Main Methods:

  • Fabrication of plasmonic uncladded OF tip immunosensors using 200 µm and 600 µm core diameter fibers.
  • Characterization of sensors based on bulk refractive index (RI) changes.
  • Detection assays for NT-proBNP concentrations ranging from 0.01 to 100 ng/mL, including interference testing.

Main Results:

  • The 600 µm OF sensors demonstrated higher sensitivity (102.8 mRIU/ng·mL⁻¹) and a lower LOD (0.11 ng/mL) compared to the 200 µm sensors (50.5 mRIU/ng·mL⁻¹, LOD 0.15 ng/mL).
  • Both sensor types showed measurable responses to NT-proBNP within the tested concentration range.
  • Control tests indicated minimal interference from common biological substances like glucose, uric acid, and creatinine.

Conclusions:

  • Plasmonic optical fiber immunosensors are effective for detecting NT-proBNP.
  • The developed sensors show promise for sensitive and rapid point-of-care heart failure diagnostics.
  • Further development could enable real-time monitoring of NT-proBNP in various biological samples.