Related Experiment Video

Updated: Jun 27, 2025

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons
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Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons

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Lineage Reprogramming: Genetic, Chemical, and Physical Cues for Cell Fate Conversion with a Focus on Neuronal Direct

Taichi Umeyama1, Taito Matsuda1, Kinichi Nakashima1

  • 1Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 819-0395, Japan.

Cells
|April 26, 2024
PubMed

Insights

Cellular reprogramming advances overcome low efficiency and subtype specificity challenges for cell-based therapies. Research explores genetics, chemistry, physics, and cell biology to control cell fate and improve therapeutic outcomes.

Area of Science:

  • Cell Biology
  • Biotechnology
  • Regenerative Medicine

Background:

  • Lineage reprogramming is a promising technology for cell-based therapy.
  • Current methods face limitations in conversion efficiency and subtype specificity.

Purpose of the Study:

  • To summarize recent advances in cellular reprogramming.
  • To discuss future directions for overcoming current limitations.

Main Methods:

  • Review of studies utilizing genetics, chemistry, physics, and cell biology.
  • Focus on controlling transcriptional networks, signaling cascades, and epigenetic modifications.

Main Results:

  • Significant progress has been made in enhancing reprogramming efficiency.
  • Improved control over cell subtype specificity has been achieved.

Conclusions:

  • Cellular reprogramming is advancing rapidly, offering new therapeutic possibilities.
  • Continued research in interdisciplinary approaches will further refine the technology.
Keywords:
direct reprogrammingepigeneticsneuronpluripotency reprogramming

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