Related Experiment Video
Updated: Jun 27, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure
Mihai Cristian Marinescu1,2, Violeta Diana Oprea1,2, Sorina Nicoleta Munteanu1,2
1Faculty of Medicine and Pharmacy, "Dunărea de Jos" University in Galați, 800216 Galați, Romania.
Insights
Serum CA 125 levels show promise as a biomarker for acute heart failure (HF). This marker aids in diagnosing congestion, predicting mortality, and guiding therapy, potentially outperforming NT-pro BNP in certain HF scenarios.
Area of Science:
- Cardiology
- Biomarker Research
- Clinical Medicine
Background:
- Heart failure (HF) presents a significant global health challenge with high mortality and frequent hospitalizations.
- Accurate diagnostic, prognostic, and therapeutic biomarkers are crucial for managing acute HF patients.
- This review focuses on the emerging role of serum CA 125 in acute HF.
Purpose of the Study:
- To review recent research on the clinical utility of measuring serum CA 125 levels in acute heart failure.
- To evaluate CA 125 as a potential diagnostic and prognostic biomarker.
- To assess its role in guiding heart failure therapy.
Main Methods:
- A comprehensive literature search was conducted across major international databases.
- PRISMA guidelines were followed for this narrative review.
- 170 relevant articles published recently were included.
Main Results:
- Studies indicate a correlation between elevated CA 125 levels and congestion in acute HF.
- CA 125 is linked to higher mortality and 6-month readmission rates post-discharge.
- CA 125 shows potential in guiding HF therapy and may surpass NT-pro BNP in specific acute HF contexts.
Conclusions:
- Serum CA 125 demonstrates potential as a valuable biomarker in acute heart failure management.
- Its ability to predict outcomes and guide treatment warrants further investigation.
- The precise mechanisms driving CA 125 upregulation in congestive HF require further elucidation.
Background:
Heart failure is a global major healthcare problem with millions of hospitalizations annually and with a very high mortality. There is an increased interest in finding new and reliable biomarkers for the diagnostic, prognostic and therapeutic guidance of patients hospitalized for acute heart failure; Our review aims to summarize in an easy-to-follow flow recent relevant research evaluating the possible use and the clinical value of measuring CA 125 serum levels in acute HF.
Methods:
A thorough search in the main international databases identified a relevant pool of 170 articles, providing recently published data for this narrative review that used PRISMA guidelines.
Results:
There are data to sustain the role of carbohydrate antigen 125 (CA 125), a worldwide used marker of ovarian cancer, in patients with heart failure. Several studies have shown links between CA 125 levels and congestion seen in acute heart failure, high mortality and readmission rates at 6 months follow-up after discharge from acute heart failure and also a role of CA 125 in the guidance of heart failure therapy. There are also clinical trials that showed that several particularities of CA 125 make it even better than N-terminal pro b-type natriuretic peptide (NT-pro BNP)-a classical and more utilized marker of heart failure) in several scenarios of acute heart failure.
Conclusions:
Although the mechanism behind the upregulation of serum CA 125 in patients with congestive HF has not been confirmed nor fully understood.
More Related Videos
04:41Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
10:12A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
Published on: August 8, 2013
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...