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Graphene in 3D Bioprinting.

Rahul Patil1,2, Stella Alimperti1,2

  • 1Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20057, USA.

Journal of Functional Biomaterials
|April 26, 2024
PubMed
Summary

Graphene materials enhance 3D bioprinting for tissue regeneration. These advanced materials offer superior properties for creating implants, paving the way for new regenerative medicine strategies.

Keywords:
3D bioprintingbonecardiovasculargrapheneneuronsregenerationskin

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Three-dimensional (3D) bioprinting is a key technology for developing tissue restoration implants.
  • Current biomaterials often lack essential mechanical, electrical, chemical, and biological properties.
  • Graphene-based materials possess unique characteristics suitable for advanced bioprinting applications.

Purpose of the Study:

  • To review recent advancements in graphene-based materials for 3D printing.
  • To explore their applications in tissue engineering and regenerative medicine.
  • To highlight the potential of graphene in 3D bioprinting for future regenerative strategies.

Main Methods:

  • Review of literature on graphene-based materials in 3D printing techniques.
  • Analysis of various graphene forms: graphene, graphene oxide (GO), reduced GO (rGO), and functional GO (fGO).
  • Examination of critical process factors: graphene dispersion, viscosity, and post-curing.

Main Results:

  • Graphene-based materials show significant potential in 3D bioprinting due to their unique properties.
  • Successful application in the regeneration of bone, neural, cardiac, and skin tissues demonstrated.
  • Control over printing parameters is crucial for optimizing construct properties.

Conclusions:

  • Graphene-based materials are highly promising for 3D bioprinting in tissue engineering.
  • These materials offer enhanced properties for developing functional tissue constructs.
  • 3D bioprinting with graphene holds translational potential for orthopedic, neurological, and cardiovascular regenerative medicine.