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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
338

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Advances in Hydrogel-Based Drug Delivery Systems.

Boya Liu1,2, Kuo Chen3

  • 1Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.

Gels (Basel, Switzerland)
|April 26, 2024
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Summary

This review explores hydrogels, versatile biomaterials ideal for drug delivery and tissue engineering. It covers their classification, advanced applications, and future potential in personalized medicine.

Keywords:
drug deliveryhydrogelinjectableocularoraltopical

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Hydrogels are 3D networks of hydrophilic polymers with high water absorption.
  • Their properties make them suitable for drug delivery, tissue engineering, and wound healing.
  • Hydrogels offer structural integrity and environmental responsiveness.

Purpose of the Study:

  • To classify hydrogels based on cross-linking methods.
  • To review synthesis, properties, and applications of hydrogels.
  • To discuss advancements in hydrogel-based drug delivery and future directions.

Main Methods:

  • Literature review on hydrogel classification and applications.
  • Analysis of recent advancements in hydrogel-based drug delivery systems.
  • Exploration of challenges and future potential in clinical translation.

Main Results:

  • Hydrogels are classified by cross-linking methods, influencing their properties.
  • Recent advancements show promise in oral, injectable, topical, and ocular drug delivery.
  • Challenges in clinical translation are identified, with potential for personalized medicine.

Conclusions:

  • Hydrogels are crucial biomaterials with diverse biomedical applications.
  • Advancements in hydrogel technology enhance therapeutic outcomes.
  • Future research should focus on overcoming clinical translation barriers and exploring personalized medicine applications.