Related Experiment Video

Updated: Jun 27, 2025

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

169

Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism

Xu Li1,2,3,4,5, Pingdong Cai1,2,3,4,5, Xinyuan Tang1,2,3,4,5

  • 1Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China.

Metabolites
|April 26, 2024
PubMed

Insights

Lactylation, a protein modification, is increasingly linked to cardiometabolic disorders (CMD). Understanding lactylation

Area of Science:

  • Biochemistry and Molecular Biology
  • Cardiovascular Research
  • Metabolic Disease Research

Background:

  • Cardiovascular disease (CVD) is a leading global cause of death.
  • Cardiometabolic disorder (CMD) involves complex cardiovascular, endocrine, and inflammatory factors.
  • Current diagnostic and treatment strategies for CMD are limited due to intricate pathology.

Purpose of the Study:

  • To explore the molecular biology of lactylation.
  • To elucidate the role and mechanisms of lactylation in cardiometabolic disorders.
  • To provide insights for improved CMD diagnosis and treatment.

Main Methods:

  • Review of existing literature on lactylation.
  • Analysis of studies linking lactylation to protein function.
  • Examination of research on lactylation in cardiac metabolic diseases.

Main Results:

  • Lactylation is a significant post-translational modification (PTM).
  • Lactylation influences protein spatial conformation and function.
  • Evidence suggests a strong correlation between lactylation and cardiometabolic diseases.

Conclusions:

  • Lactylation plays a critical role in the pathogenesis of cardiometabolic disorders.
  • Further research into lactylation mechanisms can inform novel therapeutic approaches.
  • Targeting lactylation may offer new avenues for managing CMD.

Keywords:
atherosclerosiscardiometabolic disordersdiabetesheart failurehypertensionlactylationobesity

More Related Videos

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

583
A Model of Chronic Nutrient Infusion in the Rat08:18

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

12.7K

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.5K
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.4K
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
964
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.4K
Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
6.9K
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.6K