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Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism.
Xu Li1,2,3,4,5, Pingdong Cai1,2,3,4,5, Xinyuan Tang1,2,3,4,5
1Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China.
Metabolites
|April 26, 2024
Summary
Lactylation, a protein modification, is increasingly linked to cardiometabolic disorders (CMD). Understanding lactylation
Area of Science:
- Biochemistry and Molecular Biology
- Cardiovascular Research
- Metabolic Disease Research
Background:
- Cardiovascular disease (CVD) is a leading global cause of death.
- Cardiometabolic disorder (CMD) involves complex cardiovascular, endocrine, and inflammatory factors.
- Current diagnostic and treatment strategies for CMD are limited due to intricate pathology.
Purpose of the Study:
- To explore the molecular biology of lactylation.
- To elucidate the role and mechanisms of lactylation in cardiometabolic disorders.
- To provide insights for improved CMD diagnosis and treatment.
Main Methods:
- Review of existing literature on lactylation.
- Analysis of studies linking lactylation to protein function.
- Examination of research on lactylation in cardiac metabolic diseases.
Main Results:
- Lactylation is a significant post-translational modification (PTM).
- Lactylation influences protein spatial conformation and function.
- Evidence suggests a strong correlation between lactylation and cardiometabolic diseases.
Conclusions:
- Lactylation plays a critical role in the pathogenesis of cardiometabolic disorders.
- Further research into lactylation mechanisms can inform novel therapeutic approaches.
- Targeting lactylation may offer new avenues for managing CMD.
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