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Aspergillus Endogenous Endophthalmitis as a Clue to Identifying a Delayed Lumbosacral Osteomyelitis

Muhammed Altinisik1, Yeliz Delibay Akgun2, Mustafa Erdogan2

  • 1Ophthalmology Department, Manisa Celal Bayar University, Manisa, Turkey.

Ocular Immunology and Inflammation
|April 26, 2024
PubMed
Abstract

Insights

This case report details Aspergillus-induced endogenous endophthalmitis progressing to lumbosacral osteomyelitis in an immunocompetent patient. Early misdiagnosis as ankylosing spondylitis (AS) underscores the need for thorough evaluation of atypical presentations.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Orthopedics

Background:

  • Endogenous endophthalmitis is a severe intraocular infection.
  • Aspergillus species can cause opportunistic infections.

Observation:

  • A 38-year-old immunocompetent woman presented with vision loss due to Aspergillus fumigatus endophthalmitis.
  • She later developed lower back pain, initially misdiagnosed as ankylosing spondylitis (AS).

Findings:

  • Microbiological analysis confirmed Aspergillus fumigatus in vitreous and lumbosacral biopsy samples.
  • The patient was treated with vitrectomy, intravitreal injections, intravenous amphotericin B, and antifungal therapy.

Implications:

  • This case illustrates a rare progression of fungal endophthalmitis to osteomyelitis.
  • Highlights the importance of considering fungal infections in atypical presentations and the need for interdisciplinary collaboration.
Keywords:
Aspergillus fumigatusendogenous endophthalmitisimmunocompetentosteomyelitis

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