Related Experiment Video
Updated: May 5, 2026

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus
Published on: December 16, 2022
Enlargement of the choroid plexus in pediatric multiple sclerosis
Gabriel de Deus Vieira1, Fernanda Ferrão Antônio2, Alfredo Damasceno2
1Department of Neuroimmunology, University of Campinas, Vital Brasil Street 251, Campinas, SP, Brazil. gabrieldedeusvieira@gmail.com.
Abstract:
Some studies have suggested an inflammatory role of the choroid plexus (CP) in the pathophysiology of multiple sclerosis (MS), but mainly in adult patients. We aimed to evaluate clinical and MRI parameters in patients with pediatric-onset multiple sclerosis (POMS). We included 10 patients with POMS and 16 healthy controls (HC), evaluating clinical and neuroimaging variables (cerebral cortex, CP, deep gray matter structures, and demyelinating lesions). Most patients were girls (80%), with a mean age of 15.3 years. POMS individuals had a higher CP volume (p = 0.012) and lower thalamic volume (p = 0.038) compared to HC. This study shows an enlargement of the CP and lower thalamic volume in POMS patients compared to HC.
More Related Videos
Related Concept Videos
Multiple Sclerosis l: Introduction
Increased Intracranial Pressure l: Introduction
Increased Intracranial Pressure ll: Pathophysiology
Cerebral Edema ll: Pathophysiology

