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Updated: Jun 27, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Pharmacological prevention of bone loss and fractures following solid organ transplantations: Protocol for a

Jiawen Deng1,2,3, Myron Moskalyk4, Wenteng Hou1,5

  • 1Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.

Plos One
|April 26, 2024
PubMed
Abstract

Insights

Solid organ transplant recipients face bone loss and fractures due to medical conditions and treatments. This network meta-analysis ranks anti-osteoporotic therapies to guide effective management for bone mineral density and fracture reduction.

Area of Science:

  • Transplantation Medicine
  • Bone Metabolism
  • Pharmacology

Background:

  • Solid organ transplant (SOT) recipients are susceptible to bone loss, decreased bone mineral density (BMD), and increased fracture risk.
  • Underlying conditions and immunosuppressive medications contribute significantly to skeletal fragility in SOT patients.

Purpose of the Study:

  • To conduct a comprehensive network meta-analysis (NMA) of randomized controlled trials (RCTs).
  • To rank anti-osteoporotic interventions based on their efficacy in reducing fractures and increasing BMD in SOT recipients.

Main Methods:

  • Systematic search of multiple databases (MEDLINE, EMBASE, Web of Science, CINAHL, CENTRAL, CNKI) for relevant RCTs.
  • Duplicate screening and data extraction, analyzing BMD changes (mean differences) and fracture incidences (risk ratios).
  • Utilizing Surface Under the Cumulative RAnking (SUCRA) scores for intervention ranking and RoB2/CINeMA for quality assessment.

Main Results:

  • The NMA will provide a quantitative synthesis of all available RCT data.
  • Interventions will be ranked by their effectiveness in improving BMD and reducing fracture risk.
  • The study will offer a robust comparison of various anti-osteoporotic pharmacotherapies.

Conclusions:

  • This systematic review and NMA represents the most extensive quantitative analysis on managing bone loss in SOT recipients.
  • Findings will inform clinical recommendations for pharmacotherapy to mitigate bone loss and fractures post-transplant.
  • Results will be disseminated through a peer-reviewed publication to aid clinicians and patients.

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