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Brain radiotherapy and anlotinib control primary cardiac angiosarcoma with metastases: A case report
Ying-Ying Ma1, Zhi-Ke Li, Zi-Yi Liao
1Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Rationale:
Primary cardiac angiosarcoma (PCA) is a rare and fatal disease with a poor prognosis. Whether the survival of PCA patients can be prolonged with additional treatment following complete surgical excision is controversial.
Patient Concerns:
In this case study, a 52-year-old male complained of chest tightness and pain for 7 days before admission into the hospital. Subsequently, he revisited the hospital because of dizziness and headache.
Diagnoses:
Initially, the patient was diagnosed with PCA in the right atrium by thoracic computed tomography (CT). Palliative resection identified brain, lung, and liver metastases.
Intervention:
The patient accepted multimodal combination therapy, including first-line chemotherapy and then second-line anlotinib concurrent with brain radiotherapy and immunotherapy.
Outcome:
Although anlotinib combined with brain radiotherapy controlled the growth of intracranial lesions, progression-free survival (PFS) was only 5 months, and the overall survival (OS) was only 12 months.
Lesson:
The treatment for metastatic PCA needs an in-depth exploration.
