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Related Experiment Video

Updated: Jun 27, 2025

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
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Postoperatively Noninvasive Optogenetic Stimulation via Upconversion Nanoparticles Enhancing Sciatic Nerve Repair.

Ya Li1,2, Bing Yang1,3, Yulin Wang1,2

  • 1College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.

Nano Letters
|April 26, 2024
PubMed
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This study introduces a novel optogenetics strategy using upconversion nanoparticles (UCNPs) for noninvasive peripheral nerve repair. This method promotes nerve regeneration and functional recovery with minimal trauma.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Electrical stimulation aids peripheral nerve regeneration but causes secondary damage.
  • Optogenetics offers a potential alternative for nerve repair.

Purpose of the Study:

  • To develop a noninvasive optogenetics strategy for peripheral nerve regeneration.
  • To utilize upconversion nanoparticles (UCNPs) for deep near-infrared light conversion.
  • To promote nerve repair and functional recovery with minimal trauma.

Main Methods:

  • Utilized UCNPs to convert near-infrared light into blue emission.
  • Employed adeno-associated virus encoding ChR2 for optogenetic activation.
  • Developed a UCNP-composited scaffold for in situ Schwann cell stimulation.
Keywords:
near-infrared excitationnerve regenerationoptogeneticssciatic nerve repairupconversion nanoparticles

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Main Results:

  • Optogenetic stimulation regulated RSC96 cell viability, proliferation, and nerve growth factor secretion.
  • In situ stimulation enhanced nerve sprouting, myelination, and functional recovery.
  • Achieved electrophysiological restoration and reinnervation of damaged nerves.

Conclusions:

  • The UCNP-based optogenetics strategy provides a minimally traumatic, noninvasive approach for peripheral nerve repair.
  • This method offers an enduring therapeutic stimulus for enhanced nerve regeneration.
  • The developed strategy promotes significant functional and electrophysiological recovery post-nerve injury.