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Association of anemia with all-cause mortality in Chinese centenarians: a prospective cohort study
Wangping Jia1, Shengshu Wang2, Shanshan Yang3
1Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing 400042, China.
The Journal of Nutrition, Health & Aging
|April 26, 2024
Summary
Anemia significantly increases all-cause mortality risk in Chinese centenarians. Severe anemia nearly doubles the mortality risk, highlighting the need for further research into its causes.
Area of Science:
- Gerontology
- Hematology
- Epidemiology
Background:
- Anemia is a common condition in older adults.
- Its impact on mortality in the oldest-old population, specifically centenarians, requires further investigation.
Purpose of the Study:
- To investigate the association between anemia and all-cause mortality in Chinese centenarians.
- To explore the dose-response relationship between anemia severity and mortality risk.
Main Methods:
- A prospective cohort study involving 1002 Chinese centenarians from the China Hainan Centenarian Cohort Study (CHCCS).
- Anemia was defined by hemoglobin levels: <130 g/L for men and <120 g/L for women.
- Data collected through blood analysis, home interviews, and physical examinations over a 9-year follow-up period.
Main Results:
- A total of 929 deaths (92.7%) occurred during the follow-up.
- Anemia was significantly associated with increased all-cause mortality (HR 1.289, 95% CI: 1.117-1.489).
- A dose-response relationship was observed; severe anemia increased mortality risk by approximately 1.6 times (HR 1.662, 95% CI: 1.154-2.394).
Conclusions:
- Anemia is a significant risk factor for all-cause mortality in Chinese centenarians.
- Further research is warranted to elucidate the etiology of anemia and specific causes of death in this population.
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