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Updated: Jun 27, 2025

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
The highly selective and sensitive fluorescence probe for detection of copper (II) ions and its bioimaging in vitro
Yi-Ru Wang1, Yu-Wei Tan1, Ai-Hong Zhang1
1College of Laboratory Medicine, Zhang Jiakou Key Laboratory of Organic Light Functional Materials, Hebei Key Laboratory of Neuropharmacology and Hebei Key Laboratory of Quality & Safety Analysis-Testing for Agro-Products and Food, Hebei North University, Zhangjiakou, 075000, Hebei Province, People's Republic of China.
Abstract:
We designed and developed the probe W-3 for detection of Cu2+. The results showed probe can selectively detect Cu2+, accompanied by noticeable color change. The probe can detect the Cu2+ in water samples and drinks based on absorption detection. In addition, the combination of portable test paper and the smartphone platform obtained great convenience for on-site and visual detection of Cu2+, with satisfactory sensitivity and reliability. More importantly, the fluorescence probe W-3 can be used for the detection of Cu2+ in cells and mice. Therefore, the W-3 provided potential chemical tools for detecting Cu2+ in vitro and vivo.

