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Brain elastography in aging relates to fluid/solid trendlines.

Kevin J Parker^1,2,3, Irteza Enan Kabir¹, Marvin M Doyley^1,2,3

¹Department of Electrical and Computer Engineering, University of Rochester, 724 Computer Studies Building, Box 270231, Rochester, NY 14627, United States of America.

Physics in Medicine and Biology

|April 26, 2024

Summary

This summary is machine-generated.

Brain elastography reveals that aging causes brain tissue to soften due to increased water content and decreased extracellular matrix. These changes in viscoelastic properties correlate with age-related structural shifts in grey and white matter.

Keywords:

MRI aging biphasic models brain elastography viscoelastic models

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Area of Science:

Neuroscience
Biophysics
Biomedical Engineering

Background:

Brain aging involves changes in morphology and composition.
Brain elastography shows age-related softening of viscoelastic properties.
Understanding these changes is crucial for diagnosing neurological conditions.

Purpose of the Study:

Identify causal mechanisms driving age-related changes in brain viscoelasticity.
Determine which structural factors influence grey and white matter stiffness over time.
Clarify the role of brain elastography in studying aging, disease, and injury.

Main Methods:

Analyzed elastography data from aging adults.
Integrated data from a prior study on brain composition.
Utilized a biophysical model of the brain's fluid/solid structure.

Main Results:

Age-related increases in extracellular water and decreases in extracellular matrix significantly impact brain viscoelasticity.
Grey matter stiffness decreases inversely with water fraction squared.
White matter stiffness declines inversely with water fraction to the 2/3 power, reflecting axonal structure.

Conclusions:

Brain elastography is sensitive to age-related changes in water and extracellular matrix.
These findings highlight elastography as a macroscopic indicator of microscopic structural changes.
Implications for clinical studies of aging, neurological disease, and brain injury.