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Past, Present, and Future of Noninvasive Tests to Assess Gluten Exposure, Celiac Disease Activity, and End-Organ Damage

  • 0Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Celiac Disease Research Program, Harvard Medical School, Boston, Massachusetts.
Gastroenterology +

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April 26, 2024

|

April 26, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Developing reliable biomarkers for celiac disease monitoring remains challenging. Current methods like biopsies are imperfect, necessitating better noninvasive tools to track gluten exposure and disease activity.

Area Of Science

  • Gastroenterology and Immunology
  • Biomarker Discovery
  • Celiac Disease Research

Background

  • Current biomarkers for celiac disease lack tight correlation with gluten exposure, disease activity, or end-organ damage in treated patients.
  • Significant interindividual variability in immune response to gluten complicates biomarker development.
  • The gold standard, small intestinal biopsy, has limitations in accurately assessing end-organ damage.

Purpose Of The Study

  • To review past and present efforts in establishing noninvasive biomarkers for monitoring treated celiac disease patients.
  • To identify and highlight emerging noninvasive tools with potential clinical utility.

Main Methods

  • Literature review of existing and emerging biomarkers for celiac disease.
  • Analysis of challenges in biomarker validation, including interindividual variability and biopsy limitations.

Main Results

  • No single or combined biomarker currently provides a tight correlation with gluten exposure, disease activity, or end-organ damage.
  • Existing noninvasive tools face challenges due to biological variability and limitations of current diagnostic standards.

Conclusions

  • Robust noninvasive biomarkers are needed for effective monitoring of treated celiac disease.
  • Emerging tools show promise but require further validation for clinical practice.

Keywords:

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