Remote ischaemic preconditioning for transcatheter aortic valve replacement: a protocol for a systematic review with...

Area of Science:

• Cardiology
• Interventional Cardiology
• Critical Care Medicine

Background:

• Transcatheter aortic valve replacement (TAVR) is a key treatment for aortic valve disease, but complications remain a concern.
• Remote ischemic preconditioning (RIPC) offers potential perioperative organ protection.
• The efficacy of RIPC in TAVR procedures is currently uncertain due to conflicting study results.

Purpose of the Study:

• To systematically review and meta-analyze randomized controlled trials evaluating the effectiveness of RIPC in patients undergoing TAVR.
• To determine if RIPC can reduce TAVR-related complications and improve patient outcomes.

Main Methods:

• Comprehensive search of multiple English and Chinese databases and trial registries up to December 2023.
• Meta-analysis of continuous and dichotomous data using Review Manager 5.4, with fixed or random-effects models based on heterogeneity.
• Assessment of risk of bias, evidence quality (GRADE), and publication bias (funnel plots, Egger's test).

Main Results:

• This section will present the synthesized findings from the included studies.
• Quantitative analysis of RIPC's impact on TAVR outcomes and complications will be detailed.
• Statistical heterogeneity and robustness of results will be thoroughly evaluated.

Conclusions:

• The findings will clarify the role and effectiveness of RIPC in TAVR.
• This review aims to provide evidence-based recommendations for perioperative care in TAVR patients.
• Results will be disseminated through peer-reviewed publications.