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Survival Outcomes in Thyroid Cancer Patients with Co-Occurring Breast Cancer: Evidence of Mortality Risk Attenuation
Matheus Wohlfahrt Baumgarten1, Iuri Martin Goemann2, Rafael Selbach Scheffel3
1Thyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Clinical Breast Cancer
|April 26, 2024
Summary
Breast cancer (BC) may protect against thyroid cancer (TC) mortality, particularly when the TC coexists with luminal A BC. Further research into the hormone pathways linking these cancers is needed.
Area of Science:
- Endocrinology
- Oncology
- Cancer Epidemiology
Background:
- A strong correlation exists between breast cancer (BC) and thyroid cancer (TC) incidence.
- The clinical and oncological impact of the BC-TC association requires further elucidation.
Purpose of the Study:
- To investigate clinicopathological differences between TC patients with and without BC.
- To assess the impact of a history of BC on TC survival outcomes.
Main Methods:
- Retrospective comparison of TC patients with and without BC.
- Utilized an institutional cohort and the Surveillance, Epidemiology, and End Results (SEER) database.
Main Results:
- Institutional cohort showed similar survival rates.
- SEER data indicated BC has a protective effect, reducing TC mortality (HR=0.72, P=.026).
- Higher survival rates in TC patients were specifically linked to coexisting luminal A BC (P=.015).
Conclusions:
- Hormone pathways may influence the co-occurrence of thyroid and breast cancers.
- TC patients with coexisting luminal A BC demonstrate improved survival.
- Further investigation into the mechanisms underlying the BC-TC association is warranted.
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