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Irisin combined index to diagnose central precocious puberty in girls: a cross-sectional study
Jie Wang1, Yongquan Tang1, Guanyu Chen1
1Department of Pediatrics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, 223300, China.
Insights
Serum irisin levels are elevated in girls with central precocious puberty (CPP). Irisin, combined with basal LH and uterine volume, offers a highly accurate diagnostic index for CPP in girls.
Area of Science:
- Pediatric Endocrinology
- Reproductive Medicine
- Biomarker Discovery
Background:
- Central precocious puberty (CPP) involves early sexual development in girls.
- Accurate diagnosis of CPP is crucial for appropriate management.
- Irisin's role in CPP diagnosis requires further investigation.
Purpose of the Study:
- To assess serum irisin levels in girls with varying developmental statuses.
- To determine the diagnostic utility of irisin for central precocious puberty (CPP) in girls.
Main Methods:
- A cross-sectional study involving 111 girls (43 CPP, 44 peripheral PP, 24 controls).
- Collected data included hormone levels (LH, FSH, estradiol, irisin), anthropometrics, and pelvic ultrasound.
- Girls were classified based on GnRH stimulation tests.
Main Results:
- Serum irisin levels were significantly higher in the CPP group compared to peripheral PP and control groups.
- Irisin levels positively correlated with LH, FSH, uterine volume, and bone age indicators.
- Serum irisin demonstrated high diagnostic performance (AUC 0.958, sensitivity 100%, specificity 80.6%) for CPP.
Conclusions:
- Serum irisin levels are significantly elevated in girls diagnosed with CPP.
- A combined diagnostic index using irisin, basal LH, and uterine volume shows superior accuracy for CPP diagnosis (AUC 0.994).
Background:
To investigate serum irisin levels in girls at different developmental status and explore the significance of irisin for the diagnosis of central precocious puberty (CPP) in girls.
Methods:
In this cross-sectional study 111 girls were enrolled, including 43 cases of CPP, 44 cases of peripheral precocious puberty (PPP) and 24 cases of girls with normal sexual development as controls. The data on age, weight and height, measured blood levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, and irisin were collected. Pelvic Doppler ultrasound was performed to evaluate uterine length, transverse diameter, anteroposterior diameter. The girls were divided into non-CPP group and CPP group according to gonadotropin-releasing hormone (GnRH) stimulation test.
Results:
Serum irisin levels were significantly higher in CPP group than in PPP group and normal control group. Serum irisin level was positively correlated with basal LH level, basal FSH level, peak LH level, peak LH /FSH ratio, uterine volume, bone age, and bone age index. The area under the curve, cut-off value, sensitivity and specificity of serum irisin were 0.958, 219.255 pg/ml, 100% and 80.6%. The combined diagnosis of CPP in girls by serum irisin and serum basal LH combined with uterine volume had an AUC, sensitivity, and specificity of 0.994, 97.6%, and 100%, superior to that of the single index.
Conclusions:
Serum irisin level in girls with CPP is significantly increased. An irisin combined index could help the diagnosis of CPP in girls.
