Related Experiment Video

Updated: Apr 11, 2026

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
07:27

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

Published on: May 16, 2013

18.8K

Egyptian Pediatric Guidelines for the Management of Children with Isolated Thrombocytopenia Using the Adapted ADAPTE

Galila Mokhtar1, Ashraf Abdelbaky2, Amira Adly1

  • 1Pediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo 11566, Egypt.

Children (Basel, Switzerland)
|April 27, 2024
PubMed

Insights

This study adapts clinical practice guidelines for pediatric thrombocytopenia management in Egypt. It provides consensus recommendations for diagnosing and managing isolated thrombocytopenia in children, emphasizing clinical assessment and blood smear analysis.

Area of Science:

  • Pediatric Hematology
  • Clinical Practice Guidelines Adaptation
  • Evidence-Based Medicine

Background:

  • Thrombocytopenia is common in children, with diverse causes and outcomes.
  • Accurate diagnosis and management of pediatric thrombocytopenia can be challenging.
  • This study adapts international guidelines for Egypt's healthcare setting.

Purpose of the Study:

  • To adapt high-quality clinical practice guidelines (CPGs) for pediatric thrombocytopenia management.
  • To provide consensus recommendations tailored to the Egyptian healthcare context.
  • To offer implementation tools for managing isolated thrombocytopenia in children and adolescents.

Main Methods:

  • Utilized the Adapted ADAPTE methodology to identify relevant CPGs (2010-2020).
  • An expert panel screened, assessed, and reviewed identified CPGs.
  • Formulated adapted consensus recommendations based on the best available evidence.

Main Results:

  • Developed a CPG document with consensus recommendations for pediatric thrombocytopenia management in Egypt.
  • Highlighted a scarcity of evidence for specific management protocols.
  • Emphasized initial clinical assessment, full blood count, and peripheral blood smear analysis.

Conclusions:

  • The adapted guideline provides a framework for managing isolated thrombocytopenia in Egyptian children and adolescents.
  • Initial diagnostic steps include bleeding disorder confirmation, exclusion of secondary causes, and appropriate workup.
  • The International Society of Hemostasis and Thrombosis-Bleeding Assessment Tool (ISTH-SCC BAT) can aid in screening bleeding manifestations.
  • Diagnosis of immune thrombocytopenic purpura (ITP) relies on excluding other causes.
  • Future research should evaluate the guideline's outcomes and cost-effectiveness.
Abstract

Keywords:
bleedingisolated thrombocytopeniapediatric

More Related Videos

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.5K
Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

788

Related Concept Videos

Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
363
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
388
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
471
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
392