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Related Experiment Video

Updated: Jun 27, 2025

On-Chip Endothelial Inflammatory Phenotyping
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Endothelial Reprogramming in Atherosclerosis.

Lu Zhang1, Xin Wu1, Liang Hong1,2,3

  • 1Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

Bioengineering (Basel, Switzerland)
|April 27, 2024
PubMed
Summary
This summary is machine-generated.

Atherosclerosis involves endothelial reprogramming, where cells shift to a pro-inflammatory state. Targeting these changes and epigenetic factors may help prevent this vascular disease.

Keywords:
EndITEndMTatherosclerosisendothelial cellreprogramming

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Area of Science:

  • Cardiovascular Biology
  • Vascular Cell Biology
  • Molecular Medicine

Background:

  • Atherosclerosis (AS) is a major cause of mortality, characterized by plaque formation in blood vessels.
  • AS involves complex cellular interactions, with endothelial cells (ECs) playing a critical role.
  • Endothelial dysfunction, termed 'endothelial reprogramming,' is key to AS initiation and progression.

Purpose of the Study:

  • To review the role of endothelial cells in atherosclerosis pathogenesis.
  • To summarize research on endothelial reprogramming in AS.
  • To explore therapeutic strategies targeting endothelial changes.

Main Methods:

  • Literature review of studies on endothelial cells in atherosclerosis.
  • Analysis of mechanisms underlying endothelial reprogramming.
  • Examination of epigenetic factors influencing endothelial function.

Main Results:

  • Endothelial reprogramming involves a shift to a pro-inflammatory, proatherogenic state.
  • Endothelial cell identity alterations include endothelial-to-mesenchymal transition (EndMT) and endothelial-to-immune cell-like transition (EndIT).
  • Modulating epigenetic factors can impact endothelial reprogramming.

Conclusions:

  • Endothelial reprogramming is a critical process in atherosclerosis development.
  • Targeting endothelial reprogramming and epigenetic modifications offers potential therapeutic avenues for AS.
  • Restoring endothelial balance is crucial for preventing AS progression.