Related Experiment Video
Updated: Jun 27, 2025
13:34
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
8.3K
Effects of L-Type Voltage-Gated Calcium Channel (LTCC) Inhibition on Hippocampal Neuronal Death after
Chang-Jun Lee1, Song-Hee Lee1, Beom-Seok Kang1
1Department of Physiology, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
Antioxidants (Basel, Switzerland)
|April 27, 2024
Summary
Amlodipine, an L-type calcium channel blocker, reduces zinc accumulation and neuronal death in epilepsy models. This suggests amlodipine
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Epilepsy involves excessive neuronal activity linked to L-type voltage-gated calcium channels (LTCCs).
- LTCCs mediate calcium and zinc influx, leading to oxidative stress and neuronal death via NADPH oxidase activation.
- Amlodipine (AML) inhibits LTCCs and is used for cardiovascular conditions.
Purpose of the Study:
- To investigate if amlodipine can prevent zinc translocation and accumulation in neurons.
- To evaluate amlodipine's potential to protect against seizure-induced hippocampal neuronal death.
Main Methods:
- An epilepsy model was established in rats using pilocarpine.
- Rats received amlodipine (10 mg/kg daily) after epilepsy onset.
- Cognitive function, zinc accumulation, oxidative stress, and neuronal death were assessed.
Main Results:
- Amlodipine significantly decreased excessive zinc accumulation in neurons.
- Amlodipine reduced reactive oxygen species (ROS) production.
- Amlodipine mitigated seizure-induced hippocampal neuronal death.
Conclusions:
- LTCC inhibition by amlodipine lessens neuronal zinc overload and oxidative stress.
- Amlodipine shows potential as a therapeutic agent for managing epilepsy and its damaging effects.
More Related Videos
Related Concept Videos
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
2.2K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.2K
01:17Antiepileptic Drugs: Calcium Channel Blockers
379
Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
379