Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

585
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
585
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

287
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
287
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

89
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
89
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

242
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
242
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

127
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
127
Nociception01:44

Nociception

27.9K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical outcomes of quadriceps, hamstring, and bone-patellar tendon-bone autografts for ACL reconstruction: a meta-analysis of randomized controlled trials.

Knee surgery & related research·2026
Same author

Posture evaluation and treatment in adolescents through wearable technology: a systematic review.

Frontiers in rehabilitation sciences·2026
Same author

The Role of Internal Medicine or Hospitalist Co-Management in Surgical Specialties: Implications for Adult and Elderly Plastic Surgery Patients.

Medicina (Kaunas, Lithuania)·2026
Same author

An Overview of Red Breast Syndrome: A Qualitative Systematic Review of the Literature and a Single-center Case Series.

Aesthetic surgery journal·2026
Same author

Modified Stoppa Approach for ORIF of a Paediatric Transverse Acetabular Fracture: Case Report and Systematic Review of Internal Fixation in Children.

Children (Basel, Switzerland)·2026
Same author

Anterior cruciate ligament reconstruction in elite and professional athletes: does graft choice influence return to sport and failure rate? A systematic review and meta-analysis.

International journal of surgery (London, England)·2026

Related Experiment Video

Updated: Jun 27, 2025

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

4.6K

Pain Management Strategies in Osteoarthritis.

Luca Farinelli1, Michele Riccio2, Antonio Gigante1

  • 1Clinical Orthopaedics, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60121 Ancona, Italy.

Biomedicines
|April 27, 2024
PubMed
Summary

Osteoarthritis (OA) pain management faces challenges with current treatments. This review details existing and innovative OA pain therapies, aiming for better symptom relief and function.

Keywords:
managementosteoarthritispainreviewtherapy

More Related Videos

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.2K
Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment
04:57

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment

Published on: April 26, 2024

523

Related Experiment Videos

Last Updated: Jun 27, 2025

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

4.6K
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.2K
Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment
04:57

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment

Published on: April 26, 2024

523

Area of Science:

  • Orthopedics
  • Rheumatology
  • Pain Management

Background:

  • Osteoarthritis (OA) is a degenerative joint disease characterized by significant pain, impacting patient quality of life.
  • Current OA pain management strategies often fall short, necessitating exploration of novel therapeutic avenues.
  • The complex pathophysiology of OA involves multiple joint tissues, complicating treatment approaches.

Purpose of the Study:

  • To provide a comprehensive overview of current osteoarthritis pain management treatments.
  • To describe emerging and innovative therapies for OA pain.
  • To highlight future directions in OA pain treatment based on molecular and genetic advancements.

Main Methods:

  • Narrative review of existing literature on osteoarthritis pain management.
  • Analysis of pharmacologic, nonpharmacologic, surgical, and complementary/alternative treatment modalities.
  • Exploration of ongoing research in tissue regeneration, personalized medicine, and targeted drug therapies.

Main Results:

  • Current OA treatments include a combination of pharmacologic, nonpharmacologic, and surgical options.
  • Innovative therapies are being investigated, focusing on regenerative medicine and personalized approaches.
  • Understanding OA's molecular and genetic basis is crucial for developing tailored treatments.

Conclusions:

  • Optimizing osteoarthritis pain relief requires a multimodal treatment strategy.
  • Future OA pain management will likely involve personalized medicine and advanced regenerative techniques.
  • Continued research into the underlying mechanisms of OA is essential for therapeutic breakthroughs.