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Associations between Skin Autofluorescence Levels with Cardiovascular Risk and Diabetes Complications in Patients with Type 2 Diabetes

  • 0Doctoral School of Medicine and Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Biomedicines +

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April 27, 2024

|

April 27, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Skin autofluorescence (SAF) correlates with cardiovascular risk and HbA1c in type 2 diabetes mellitus (T2DM). An SAF cut-off of 2.35 effectively identifies patients at very high cardiovascular risk.

Area Of Science

  • Endocrinology
  • Cardiology
  • Biomedical Engineering

Background

  • Advanced Glycation End Products (AGEs) are implicated in type 2 diabetes mellitus (T2DM) pathophysiology and cardiovascular diseases (CVDs).
  • Non-invasive assessment of AGEs via skin autofluorescence (SAF) is crucial for managing T2DM and associated cardiovascular risks.
  • Understanding the relationship between SAF, cardiovascular risk, and diabetic complications is vital for patient management.

Purpose Of The Study

  • To investigate the association between SAF levels, cardiovascular risk stratification, and diabetic complications in T2DM patients.
  • To determine the utility of SAF as a non-invasive biomarker for cardiovascular risk in T2DM.
  • To identify an optimal SAF cut-off value for predicting very high cardiovascular risk in T2DM.

Main Methods

  • A cross-sectional study involving 885 T2DM patients at Consultmed Hospital, Iasi, Romania.
  • SAF levels were measured using the AGE Reader™ device.
  • Cardiovascular risk categories, HbA1c, and demographic data were assessed and analyzed using multivariate regression.

Main Results

  • Elevated SAF levels were significantly associated with higher cardiovascular risk and HbA1c values in T2DM patients.
  • A 1 SD increase in HbA1c correlated with a 0.105 SD increase in SAF levels (p < 0.001) after adjusting for age and eGFR.
  • An SAF cut-off of 2.35 demonstrated 67.7% sensitivity and 56.2% specificity for identifying very high cardiovascular risk (AUC = 0.634, p = 0.001).

Conclusions

  • Elevated SAF levels are a significant indicator of increased cardiovascular risk and poorer glycemic control (HbA1c) in T2DM.
  • The SAF cut-off of 2.35 is identified as an optimal threshold for predicting very high cardiovascular risk in this T2DM cohort.
  • SAF measurement offers a valuable, non-invasive tool for cardiovascular risk assessment in patients with type 2 diabetes mellitus.

Keywords:

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