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Published on: January 28, 2019
Trace Amine-Associated Receptors' Role in Immune System Functions
Vyacheslav I Moiseenko1, Vera A Apryatina1, Raul R Gainetdinov1
1Institute of Translational Biomedicine, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
Trace amines and their associated receptors (TAARs) interact with immune cells, influencing immune responses. Understanding these interactions may lead to new treatments for immune system disorders.
Area of Science:
- Immunology
- Neuroscience
- Biochemistry
Background:
- Trace amines are biogenic amines structurally similar to neurotransmitters.
- Trace amine-associated receptors (TAARs) are G protein-coupled receptors that sense trace amines.
- TAARs are implicated in olfaction, neuropsychiatric disorders, and immune cell function.
Purpose of the Study:
- To review the interaction between trace amines and their receptors with immune cells.
- To overview the role of TAARs in myeloid and lymphoid cell function.
- To highlight the potential of targeting the trace amine system for immune disorder treatments.
Main Methods:
- Literature review of existing research on trace amines, TAARs, and the immune system.
- Analysis of data on TAAR expression and function in various immune cell populations.
- Synthesis of information regarding the regulatory role of the trace amine system in immunity.
Main Results:
- Trace amine-associated receptors are expressed in various immune cell populations.
- TAARs play a role in the function of both myeloid and lymphoid cells.
- The trace amine system has a regulatory role in immune functions.
Conclusions:
- Further research into the trace amine system's role in immunity is warranted.
- Understanding TAARs' molecular mechanisms could lead to novel therapeutic strategies for immune dysfunctions.
- Investigating the chemotactic role of TAARs may offer new treatment approaches for immune-related disorders.
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